Effect of Hydromethanolic Extract of Stem Bark of Lannea kerstingii on Anemia and Hepcidin Production

Introduction: Stem bark of Lannea kerstingii is used in Togo for its anti-anemic effect. The aim this study was to verify the efficacy extracts L. kerstingii’s treatment anemia and explore mechanism action. Materials Method: stem collected city Kpalimé, located at 120 km northwest Lomé. Hydromethanolic extract obtained by evaporation. Two protocols were carried out 20 twelve-week-old rats that had an average weight 175.17±16.8 grams used. first protocol consisted inducing intraperitoneal injection phenylhydrazine, then force-feeding them with measuring effect on their hemoglobin levels. second investigated serum hepcidin level, after oral administration carbon tetrachloride rats. Hepcidin levels measured ELISA technique. Results: significantly corrected induced phenylhydrazine use: fact, received corrected. Control folic acid a correction too. But, only saline remained anemic. However, no correlation between level consumption established. Conclusion: hydroethanolic increase anemic main challenge needs be solved determining minimum dose consumed ensure effectiveness.
 Keywords: kerstingii, anemia, hepcidin, wistar rat.